We are thrilled to announce that the Steinmann Group has received a Project Grant from the Novo Nordisk Foundation (NNF) to study the molecular basis of immunoglobulin light-chain misfolding.

Proteins sometimes fold the wrong way and form clumps that harm organs. In primary amyloidosis, certain immune-system proteins called light chains are especially prone to this. We will study the basic physical chemistry that decides whether these proteins stay as stable pairs (dimers) or are prone to form clumps. Using advanced computer simulations and standard biophysical measurements, we will map how natural sequence differences change shape, motion and stability, and we will identify small molecules that help the native dimer hold together.

The main outcome will be an openly shared Light-Chain Structural Atlas with models, dynamics and binding-site maps. This fundamental research could guide future strategies to prevent misfolding in primary amyloidosis and related diseases.